Sources of reactive oxygen species in skeletal muscle during the exercise.

Skeletal muscle constantly generates reactive oxygen species (ROS) through the monoeletronic reduction of molecular oxygen. The traditional view states that during exercise mitochondria is the major site of ROS generation, under the control of skeletal muscle oxygen uptake. However this is not confirmed by in vivo and in vitro experiments. In fact the ROS generation is associated to an increased muscle contractile activity. The objective of this paper is to presents the possible sites and regulatory mechanisms of ROS generation in skeletal muscle. The roles of the different sites of ROS generation in skeletal muscle still are to be elucidated, but evidences points out mitochondria and xantine oxidase as the principal responsible for ROS generation in skeletal muscle during exercise.

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