LDL is a low-density lipoprotein, very rich in cholesterol and cholesteryl esters, contending one specific apoprotein. The bilding of apoprotein to an LDL receptors initiates process of endocytosis, which conveys the LDL and its receptor into the cell within an endosome. The endosome fuses with a lysosome, which contains enzymes that hydrolyze the cholesteryl esters, releasing cholesterol and fatty acid into the cytosol, and the LDL receptor returned to the cell surface, to function again in LDL uptake.
OLIVEIRA, E. A. Uptake cholesterol enter cells by receptor-mediated endocytosis Biblioteca Digital de Ciências, 12 apr. 2007. Available in: <http://www.ib.unicamp.br/lte/bdc/visualizarMaterial.php?idMaterial=465>. Access in: 25 may. 2013.
Educational Technology Laboratory Department of Biochemistry Institute of Biology Universidade Estadual de Campinas - Unicamp Cidade Universitária Zeferino Vaz Rua Monteiro Lobato, 255 Campinas SP, Brasil 13083-862